According to WHO, diabetic retinopathy is responsible for 3-7% of the total blindness in Asia. According to the World Diabetes Atlas, India is projected to have around 77 million people with diabetes. Hyperglycemia and dyslipidemia are two major metabolic changes seen of diabetes mellitus. Diabetes is commonly accompanied by disturbances in the production and clearance of plasma lipoproteins.
Methodology: Hospital based observational study.This study was carried out in the department of Ophthalmology, RVM Hospital, Siddipet, Telangana state during the period of January 2019 to February 2020. Convenience sampling method and Stratified random method is used to collect the data. Study sample is 300. Data analyzed using SPSS (Statistical Presentation System Software) (version 21.0).
Results: Each group comprised of 53 males and 47 females. Mean age in each group was 61.25 ± 6.19, 56.94 ± 5.97 and 61.85 ± 6.77 years. Among the study patients, the duration since diagnosis of diabetes mellitus ranged from 5-25 years. The mean duration in group 1 and group 2 was 9.04 ± 4.65 and 6.24 ± 1.29 years respectively. In the group 1, Mild NPDR retinopathy was present in 43 % of patients, moderate NPDR in 30 % of patients, severe NPDR retinopathy in 11% of patients, very severe NPDR in 7% and proliferative retinopathy in 9% of patients. Among these 30 patients (30%) had CSME. On observation of lipid sub fractions in DR subjects with and without CSME, it was found that mean serum cholesterol concentration was significantly higher in the retinopathy subjects with CSME as compared to those without CSME(p=0.001).
Conclusion: The present study demonstrated statistically significant correlation between diabetic retinopathy and hypercholesterolemia.