A clinical study of diabetic patients who underwent the retinopathy while in the deficiency of calcitriol: Tertiary care teaching hospital based study

Dr. Subodh Kumar Agarwal; Dr. Rashmi Agarwal

doi:10.33545/26638266.2019.v1.i1a.72

A clinical study of diabetic patients who underwent the retinopathy while in the deficiency of calcitriol: Tertiary care teaching hospital based study

Author(s): Dr. Subodh Kumar Agarwal and Dr. Rashmi Agarwal

Abstract:
Background: Diabetes mellitus continues to be a tremendous health burden in America. In 2007, the prevalence of diabetes was estimated to be 23.6 million people, or 7.8% of the population. Diabetes mellitus (DM) is a large public health disorder which affects more than 300 million individuals worldwide, with significant morbidity and mortality. The prevalence of Diabetic Retinopathy varies from 20% to 80% in different studies according to previous literature. The increased physical activity is highly associated with less severe levels of Diabetic Retinopathy. Serum 25-hydroxyvitamin D (25(OH) D) levels were almost decreased in type 2 diabetic patients with retinopathy when compared with type 2 patients who had no microangiopathy. Objectives the purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency.

Materials and Methods: As we have taken, 104 subjects of both the sexes, after obtaining informed consent; 52 being cases with Diabetic Retinopathy and 52 without Diabetic Retinopathy, using convenient sampling. Exclusion criteria included patients having known risk factors of diabetic retinopathy mainly people who were hypertensive or pregnant and lactating women. The serum of the patientsâ€™ samples were assessed by Chemiluminescence immunoassay [CLIA] of serum 25 hydroxy Vitamin D determination.

Results: Our study included 52 patients with Diabetic Retinopathy and 52 without Diabetic Retinopathy. Mean age of the DR cases was 51.0 Â±10.4 years and those without DR were 52.0 Â±8.2 years. There were 25 (50%) males in patients with DR while 33 (66%) in patients without DR. The P-value was highly significant between both the groups (p=0.001).

Conclusion: There is a statistically significant association between vitamin D (Calcitriol) deficiency and Diabetic Retinopathy (DR).

DOI: https://doi.org/10.33545/26638266.2019.v1.i1a.72

Pages: 39-42 | 1349 Views 436 Downloads

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